Exosomes

Exosomes for Hair Restoration

What’s more frustrating than hair loss (alopecia)? We use our hair to signal beauty and youth; it is our pride and joy.  Yet new research in China found that people perceive they are going bald earlier than past generations, even in their 20s! In the study 60% of participants self-reported that they were losing significant amounts of hair. In general, 85% of men’s hair will have thinned out significantly by the age of 50.

Not just men experience pattern baldness. More than 50% of women will experience noticeable hair loss, often because of female-pattern hair loss. Because of rigid beauty standards for women, there may be an even greater stigma attached to their hair loss, and greater emotional damage.

What causes hair loss

Age is the obvious cause of hair loss; in fact, 95% of men’s hair loss is caused by male pattern baldness, but hormonal changes, autoimmune diseases, thyroid disorders, and stress can contribute as well. Some assert that vegan diets may contribute to hair loss. Vitamin deficiencies have been indicated too, such as zinc, vitamin D, and other nutrients.

How does stress contribute?

There are multiple stages in hair growth and loss. Stress can move hair out of the growth phase, causing hair to fall out and not regrow. Studies on animals have shown stress to cause this to occur. Millennials report higher levels of stress than older generations, and more difficulty in coping, which may be one reason they report more hair loss.

The impact of hair loss on self-image

Studies have shown that women are drawn to men with hair, and some have pointed to hair as a factor in success in politics (Eisenhower is the only bald man to be elected to the White House in modern times. Men respond to this prejudice with body dysmorphia and other psychological problems that are difficult to talk about.

What remedies for hair loss have traditionally been used?

While in older times, herbs like lavender, rosemary, and thyme were used to treat hair loss, in modern times more people try methods like hair regrowth pharmaceuticals. Some of these drugs can cause rapid heart rate, unwanted hair growth and even sexual dysfunction. So far, there are hair restoration    like hair transplant surgery. This is only implicated when only the top of the head is affected. Skin is transplanted from the back to the top. Multiple surgeries may be need, and hereditary hair loss will still occur. The surgery can be expensive and painful. No one wants to be forced to use a product every day or lose their benefits (their hair) again. Who doesn’t dream about simply regrowing their own hair?

Exosomes are the next frontier in hair restoration

Exosomes, which ethically come from birth tissues (see http://amnioticdoctors.com/top-uses-of-amniotic-membrane-to-heal-the-eyes for a more detailed explanation), contain RNA and mRNA, which is the initiator of protein manufacture. They produce signals that create bodily function including cellular growth. Basically, they send messages and direct cells how to act.

Exosomes are released by cells when they fuse together.

The technical stuff

Exosomes are extracted from mesenchymal stem cells and contain growth factors SCF, and melanocyte. Exosomes are trophic, or regenerative, therapies. They are naturally bioactive amnion-based products that act as paracrine effectors. The stimulating effect is by the transfer of information. Exosomes provide excellent nutrition to cells. Collectively, exosomes and microvesicles are known as EVs.

They contain TGFB3, which converts inflammatory cells into anti-inflammatory regularly cells. VEGF and MIP-1 stimulate the formation of blood vessels and recruits mononuclear cells to the scalp. Exosomes contain FGF, a potent growth factor that affects many kinds of cells. When they tell a cell to deliver mRNA, it stimulates other cells to generate proteins that repair damage.

Where do these cells come from? They largely come from amniotic cells or Wharton’s Jelly (insert link).

(Insert link for exosomes for cancer once it’s posted) They might be used to treat Lyme disease and RA.

How do exosomes for hair loss work?

In Spring of 2019, physicians and researchers began to agree that exosomes have great potential in hair restoration. Studies are still investigating how exosomes work to regrow hair. Hair follicles have mature cells called HFSCs and dermal papilla cells (DPCs) and exosomes act on these.

There are two methods for inserting exosomes for hair loss. A serum is manufactured and filtered to isolate exosomes. The serum is injected with local anesthetic into the superficial dermis of the scalp. The patient returns to most normal activities the next day but is encouraged to avoid sweating. Some soreness may exist for around a week.

Second, like micro-needling, the scalp is punctured to deliver exosomes with tiny needles. So far in the research, this appears to be the faster method to regrow hair.

With exosome therapy for hair loss, the hair growth cycle remains and hair strands become thicker and healthier

Conclusion

Exosomes are an aspect of regenerative treatment, and these cells heal, repair, stimulate, and restore cells and tissues. Do exosomes, with time and research, have the potential to beat all existing forms of hair transplantation? Time will tell! Use the contact form below to find a doctor who can tell you if exosomes for hair loss is right for you.

References

https://my.clevelandclinic.org › health › diseases › 16921-hair-loss-in-women

https://www.healthline.com/health-news/why-millennials-losing-hair-earlier#4
https://www.ncbi.nlm.nih.gov/pubmed/30924959